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Evidence-Based Practice

Forming a Research Question

To get the best answers you must ask the right questions! In healthcare, this often means using the PICO(t) acronym to form your research question.

PICO(t)

When forming a research question, PICO(t) stands for:

Population
  • Characteristics like age, gender, ethnicity
  • Health issues like diabetes or access to healthcare
Intervention
  • Prescription, surgery, manual therapy, policy
  • Setting or geography
Comparison
  • Second intervention or no intervention
Outcomes
  • Lower blood glucose levels or BMI
  • Timing
Type of Studies
  • Type of questions
  • Type of studies
  • Optional

PICO(t) can be used to answer a variety of different types of questions.

  • Question Type: Intervention or therapy. Used to determine which treatment leads to the best outcome.
  • Question Type: Etiology. Used to determine the greatest risk factors or causes of a condition.
  • Question Type: Diagnosis or diagnostic test. Used to determine which test is more accurate and precise in diagnosing a condition.
  • Question Type: Prognosis or prediction. Used to determine the clinical course over time and likely complications of a condition.
  • Question Type: Meaning. Used to determine the meaning of an experience for a particular individual group or community.

Other Ways to Structure a Research Question

PICO(t) is often used when comparing interventions for a population, but there are many other ways to structure a research question. The following links explain such structures as SPIDER, PEO, and PCC.